[PDF][PDF] Understanding the intersections between metabolism and cancer biology
MG Vander Heiden, RJ DeBerardinis - Cell, 2017 - cell.com
MG Vander Heiden, RJ DeBerardinis
Cell, 2017•cell.comTransformed cells adapt metabolism to support tumor initiation and progression. Specific
metabolic activities can participate directly in the process of transformation or support the
biological processes that enable tumor growth. Exploiting cancer metabolism for clinical
benefit requires defining the pathways that are limiting for cancer progression and
understanding the context specificity of metabolic preferences and liabilities in malignant
cells. Progress toward answering these questions is providing new insight into cancer …
metabolic activities can participate directly in the process of transformation or support the
biological processes that enable tumor growth. Exploiting cancer metabolism for clinical
benefit requires defining the pathways that are limiting for cancer progression and
understanding the context specificity of metabolic preferences and liabilities in malignant
cells. Progress toward answering these questions is providing new insight into cancer …
Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.
cell.com